A New Era Of Topical Skincare Products Claim To Match The Results Of In-Clinic Tweakments—But Can They Really?
The experts weigh in
Skincare has always been at the centre of beauty: from the classic blue tub of Nivea Crème to Tretinoin, topical formulations keep the industry alive. But lately, a new generation of products has entered the fold, claiming far more in terms of results, even those comparable to professional procedures. But how do they measure up? I investigated.
A new era of skincare
This 'new era' of skincare recognises the mainstreaming of aesthetic treatments like filler, Botox and polynucleotides, and thus, that we want better, smarter results for our skin. It also knows we are savvy, and that for the most part, we're willing to invest to see a real difference. But what these formulations offer, or claim to offer, are results similar to those of the in-clinic tweakments at a much lower cost. Seemingly, making them the best of both worlds.
Let's start, for example, with a couple of the industry's latest launches by well-known and beloved skincare brands. The Ordinary's Volufiline 92% + Pal-Isoleucine 1% is a product that uses innovative ingredients (Volufiline, otherwise known as Sarsasapogenin, and Palmitoyl Isoleucine) to supposedly address causes of lost volume at their core, rather than just masking the effects. It's designed to be used on areas such as the temples, smile lines and cheeks, where we see evidence of lost collagen and elastin, most commonly the more we age. For this reason, the product has been dubbed a 'filler alternative' online, and while the brand never explicitly embraces this claim, it does do a good job of describing benefits that sound an awful lot like filler.
Another product that's caught my eye lately is Skinceuticals' Advanced RGN-6 Rejuvenation Cream. The brand has a history of creating clever formulations that could be said to offer 'tweakment-like' results, such as P-Tiox, which many compared to Botox. According to the brand, the new cream was "inspired by laser regeneration science" and uses peptides such as Acetyl Tetrapeptide-9. Results, the brand says, include reduced pigmentation by 36%, a 35% increase in elasticity and firmness, and an 18% reduction in the appearance of wrinkles. Its primary use is to aid skin post-procedure, but there are clear comparisons to laser treatments, too. “Advanced RGN-6 marks a new type of cream that has been designed to be used not only alongside laser treatment, but as a powerhouse standalone formula," says Dr Wassim Taktouk, an Aesthetic Doctor who works with the brand.
These two are not alone. Emma Lewisham's Supernatural Vitale Face Elixir has been dubbed part of the 'Botox in a bottle' trend online, and Roc's Derm Correxion Lip Volumizer was developed by dermatologists and plastic surgeons to "work instantly and over time to deliver a dramatic plump", which is said to be 'inspired by lip injections."
It's clear skincare marketing has a clear new focus: tweakment-like results. Brands know we want these, and they know we'd rather get them for less. But is there real weight behind the claims?
Can topical skincare products really compare to tweakments?
Many of these products do hydrate, plump, and smooth the skin—the real question is to what extent and for how long. Procedures like fillers, Botox, lasers, and skin boosters deliver immediate results that can last months to years, often improving over time. In contrast, topical skincare typically works more slowly and produces subtler changes. And in some cases—like plumping balms—the effect is mostly instant gratification (your lips look fuller) but fades quickly.
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Unfortunately, most skin experts agree that even this new wave of topical products delivers within the same limits: results are either subtle and slow to appear, or instantly noticeable but superficial and short-lived.
Speaking about The Ordinary's Volufiline 92% + Pal-Isoleucine 1%, for example, Dr. Toni Phillips, an aesthetic doctor and Group Clinical Director for SK:N Clinics, notes that, "while products like this can enhance hydration and give the skin a softer, more cushioned look, they cannot recreate the lift, contour or volume restoration that true dermal fillers provide." She adds: "Topical formulas sit within the upper layers of the skin, whereas fillers replace lost structure at a much deeper level."
"The benefits are subtle, slow-building and low-risk—but they won’t replicate the lift, precision or immediate impact of hyaluronic acid fillers," adds Aesthetic Doctor, Dr Jessica Halliley.
Dr Sonia Khorana, cosmetic doctor and dermatology expert, agrees that when it comes to products with 'Botox-like' effects, the outcome doesn't compare. "You do not get the same results out of a bottle as you do with injections, as they do not inhibit muscle contraction, as a serum cannot penetrate the muscle. The results are also not long-lasting like they are with Botox," she tells me. "It's important to note that these serums are not a replacement for professional medical treatments like Botox."
What the experts want consumers to remember, therefore, is that these products work on a different level to injectables and professional treatments, mostly at the surface. Many of the innovative, modern ingredients they use also don't have nearly as much scientific evidence as aesthetic procedures do in terms of smoothing, plumping and filling in the long-term.
On a regulatory level, too, there is a clear difference between cosmetics and aesthetic treatments like injectables, Kamal Kaur of The Cosmetic Regulator told me last year. "Aesthetic injectable treatments are medicinal procedures and work on a physiological level; cosmetics should not be compared to these treatments."
It's therefore important to manage expectations: as it stands, a skincare formula you can buy for £20 probably isn't going to stop you from wanting Botox or filler, if these are your desired treatment results. However, that's not to say they're not valuable, and can be a great addition to your skincare routine.
These products have been created with the aesthetic experience in mind, meaning that although they might not produce transformational results, they can work over time, especially when used in tandem with professional procedures. Most experts I spoke to agreed that a product like The Ordinary's or Emma Lewisham's can be a great additional, complementary step to achieving those longer-term, deeper, structural changes — perhaps more so than other products in your existing routine, because these formulas are targeted and have been created with this in mind.
"Think of it [The Ordinary's Volufiline 92% + Pal-Isoleucine 1%] as a supportive step: great for soft, natural-looking plumpness, helping maintain results between appointments, or offering a gentle boost if you’re not ready for injectables," says Dr Halliley. This also applies to products like RoC's, Emma Lewisham's and Skinceuticals; the latter of which I recently used post-microneedling and laser on my neck, and found to be a lovely formulation for recovery. For this reason, they're worth investing in: just be sure to understand what they can — and cannot — realistically achieve.

Rebecca is a freelance beauty journalist and contributor to Marie Claire. She has written for titles including Refinery29, The Independent, Grazia, Coveteur, Dazed, Stylist, and Glamour. She is also a brand consultant and has worked with the likes of The Inkey List on campaign messaging and branded copy. She’s obsessed with skincare, nail art and fragrance, and outside of beauty, Rebecca likes to travel, watch true crime docs, pet sausage dogs and drink coffee. Rebecca is also passionate about American politics and mental health awareness.