Oscar-nominated for the third time, take a look back at the star's career moments
What: My Week With Marilyn
The actress hit the Oregon trail circa 1845 in this Western indie flick directed by Kelly Reichardt.
The indie darling earned her first Best Actress Academy Award nomination for her portrayal of exasperated wife Cindy opposite Ryan Gosling in Blue Valentine.
The actress was handpicked by director Martin Scorcese to play the role of Leonardo DiCaprio's deceased - but all too present - wife in this psychological thriller.
Williams played the female lead - a seductress named 'S' - in this thriller with Ewan McGregor and Hugh Jackman.
Proving her acting talents in indie director Kelly Reichardt's melancholy film about a girl who experiences a series of setbacks, Williams shows that she doesn't need a full face of war paint and a stylish coif to hold an audience captive.
Williams met her future partner and father of her daughter, Matilda, on the set of Ang Lee's provocative film about two cowboys who pursue a forbidden love affair. Her role as Ledger's on-screen wife, Alma, also earned her a Best Supporting Actress nomination from the Academy.
The star's supporting role as Coco Rivington in this film, where six different actors play Bob Dylan, wasn't her most memorable on-screen acting moment, but her take on swinging sixties style is pitch-perfect.
Director Wim Wenders cast Williams as Lana in this exploration of post-9/11 malaise.
In this quirky flick, Williams played a 1950s suburban girl who starts to question her sanity... and decides she wants a lobotomy. Things aren't all bad - that net veil is divine.
The actress played a librarian opposite Peter Dinklage in this BAFTA-winning indie flick.
Williams starred opposite Christina Ricci as Harvard pal Ruby in this exploration of depression and drug abuse based on Elizabeth Wurtzel's acclaimed book.
Williams tries her hand at a British accent as we see her play Brighton girl Holly, and witness the trials and tribulations she goes through with best friend Marina (played by Anna Friel).
Williams made the leap from small to big screen with a role in this slasher flick, where she mastered the art of screaming in fear. Who would have known it would be the start of such a rich and lauded film career?
The actress made her small screen debut playing girl-with-a-past Jen as one of the key quartet - alongside Katie Holmes, James Van Der Beek and Joshua Jackson - on this hit teen show chronicling four friends and their relationships.